PLK1 overexpression as a dual-role biomarker and therapeutic vulnerability in pulmonary adenocarcinoma
PLK1 overexpression signifies aggressive disease and poor prognosis in LUAD, mechanistically linked to cell cycle dysregulation and an immunosuppressive microenvironment. Our findings nominate PLK1 as a promising therapeutic target and biomarker, warranting further investigation into PLK1-directed therapies.
Authors
- Lukuan You
- J Li
- Yi Xu (ORCID: https://orcid.org/0000-0003-2126-6054)
- Yu Fu (ORCID: https://orcid.org/0000-0002-2413-3858)
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2026-01-15
- DOI
- https://doi.org/10.7717/peerj.20618
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 36.44