Identification and validation of an endotoxin tolerance–based prognostic model with therapeutic insights in sepsis

An ET-anchored, 10-gene signature captures a clinically relevant axis of sepsis-associated immunosuppression and enables short-term mortality risk stratification. Integration with age yields a simple nomogram with stable internal performance. Multilayer validation (transcript, protein, single-cell) supports biological plausibility. Prospective multicenter studies with richer clinical annotation and functional assays are warranted to confirm generalizability and to evaluate ET-guided immunomodulatory strategies.