GapR is a nucleoid-associated protein that stiffens and overtwists DNA to promote transcription and replication
3GapR is a DNA structuring protein that binds AT-rich and overtwisted, positively supercoiled DNAGapR binding stiffens DNA, limits plectoneme formation, and melts undertwisted DNA at higher forceGapR binding modes exert opposing effects on transcription initiation while promoting elongation.
Authors
- Monica S. Guo (ORCID: https://orcid.org/0000-0002-6720-2323)
- Ryo Kawamura
- John F. Marko
Institutions
- Northwestern University (US)
- University of Washington (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-14
- DOI
- https://doi.org/10.64898/2026.01.13.699244
- Primary Topic
- Bacterial Genetics and Biotechnology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Institutes of Health