Characterizing the impact of traumatic brain injury phenotype on coagulation dynamics in severely injured patients
TBI patients demonstrated patterns consistent with prehospital fibrinogen consumption and fibrinolysis. Unique differences were observed between the phenotypes of TBI, with severe isolated TBI patients exhibiting lower levels of vWF, Coagulation Factor VIII, Coagulation Factor XIII alpha chain, and PAI-1. These findings highlight the temporal and injury-phenotype contributions to TBI-induced coagulopathy.
Authors
- Julie Goswami (ORCID: https://orcid.org/0000-0002-6211-0518)
- Valerie J. Tutwiler (ORCID: https://orcid.org/0000-0003-1213-4447)
- Joseph Hanna
- Sameer Ahmad
- Andrew R. Gosselin
Institutions
- Rutgers, The State University of New Jersey (US)
- Johnson University (US)
- Rutgers Sexual and Reproductive Health and Rights (NL)
Publication Details
- Journal
- Thrombosis Research
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1016/j.thromres.2026.109583
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- New Jersey Commission on Spinal Cord Research