Transcription Factor Binding and Individual Genetic Risk of Valproate Teratogenicity
These findings suggest that VPA-induced disruption of <i>EP300-</i>related gene regulation is a teratogenic mechanism that is common to heterogeneous birth defect types and sensitive to genetic variation. This has implications for the development of pharmacogenomic risk biomarkers and safer drugs for women of childbearing potential.
Authors
- Patricia Dugan (ORCID: https://orcid.org/0000-0001-6199-1870)
- Aleksei Rakitin (ORCID: https://orcid.org/0000-0002-8001-3463)
- Ruth Ottman (ORCID: https://orcid.org/0000-0001-7074-242X)
- Terence John O'Brien (ORCID: https://orcid.org/0000-0002-7198-8621)
- Torbjörn Tomson
- Michael V. Boland (ORCID: https://orcid.org/0000-0003-2506-7095)
- John Craig (ORCID: https://orcid.org/0000-0002-9219-9795)
- Anne Rochtus (ORCID: https://orcid.org/0000-0002-3266-9126)
- Hyunmi Choi
- Danielle Molinari Andrade (ORCID: https://orcid.org/0000-0003-0953-2698)
- Carl W. Bazil
- J Graham
- Andreja Avberšek (ORCID: https://orcid.org/0000-0002-1352-5127)
- Stefan Wolking (ORCID: https://orcid.org/0000-0002-1460-6623)
- P Perucca
- F Vajda
- Dana Jazayeri (ORCID: https://orcid.org/0000-0002-6343-0812)
- Nicholas William Wood (ORCID: https://orcid.org/0000-0002-9500-3348)
- Mark Rees
- RODNEY A. RADTKE
- Rikke S. Møller (ORCID: https://orcid.org/0000-0002-9664-1448)
- Daniel J. Costello (ORCID: https://orcid.org/0000-0001-6023-8246)
- Wolfram S. Kunz (ORCID: https://orcid.org/0000-0003-1113-3493)
- AE Anderson
- Andrea Jorgensen (ORCID: https://orcid.org/0000-0002-6977-9337)
- Emilio Perucca (ORCID: https://orcid.org/0000-0003-3232-1389)
- M. Mart�nez Ferri
- D. R. Fish
- Arjune Sen
- N Delanty
- Orrin Devinsky
- Daniel Sandvik
- Federico Zara
- Mojgansadat Borghei
- Ben Francis
- Martin Krenn
- Costin Leu
- Maria Paola Canevini
- Bianca Berghuis
- Lieven Lagae
- Anja C.M. Sonsma
- Antonio Gambardella
- Wayne Frankel
- Elena Vianca
- Anthony G. Marson
- Mohamad Mikati
- Marina Nikanorova
- Bobby Koeleman
- Michael M. Johnson
- Alison Hitchcock
- Josemir W. Sander
- Massimo Pandolfo
- Joseph Willis
- Pasquale Striano
- Sarah R. Langley
- Patrick Kwan
- Sameer Zuberi
- Colin Patrick Doherty
- Yvonne G. Weber
- EPIGEN for EpiPGX
- Sarah Weckhuysen
- Elena Zambrelli
- Ellenr Campbell
- Fritz Zimprich
- Pauls Auce
- Roland Krause
- Prashant Srivastava
- Sarah Peter
- Ana Antonic-Baker
- Holger Lerche
- Marian Todaro
- Ingrid E. Scheffer
- Nicole Walley
- Mark McCormack
- Dina Battino
- Gianpiero L. Cavalleri
- David Goldstein
Institutions
- Belfast Health and Social Care Trust (GB)
- The Royal Melbourne Hospital (AU)
- Royal Children's Hospital (AU)
- The University of Melbourne (AU)
- University of Luxembourg (LU)
- University of Milan (IT)
- Utrecht University (NL)
- Karolinska Institutet (SE)
- University of Indonesia (ID)
- Epilepsy Research UK (GB)
- University Hospital Mútua de Terrassa (ES)
- Ospedale San Paolo (IT)
- Epilepsy Foundation (AU)
- Alfred Health (AU)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- University College London (GB)
- Epilepsy Society (GB)
- University of Tartu (EE)
- Monash University (AU)
- Victoria University (AU)
- KU Leuven (BE)
Publication Details
- Journal
- Neurology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1212/wnl.0000000000214570
- Citations
- 1
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 41.22