Influence of the Intervertebral Disc Microenvironment on Matrix Synthesis and Metabolism in Goat Nucleus Pulposus Cells
These findings highlight the critical role of pH in regulating NP cell function and show that interactions between microenvironmental factors impact cell behavior more than isolated effects. Incorporating physiologically relevant microenvironments may improve regenerative therapy development and enhance translation from preclinical models to clinical application.
Authors
- Niamh Wilson
- Jake McDonnell (ORCID: https://orcid.org/0000-0002-8002-8024)
- C Buckley
- Emily E. McDonnell (ORCID: https://orcid.org/0000-0002-5064-9591)
- Tara Ní Néill
- Pieter A. J. Brama
Institutions
- University College Dublin (IE)
- Royal College of Surgeons in Ireland (IE)
- Trinity College Dublin (IE)
- Mater Misericordiae University Hospital (IE)
- Advanced Materials and BioEngineering Research (IE)
Publication Details
- Journal
- JOR Spine
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1002/jsp2.70160
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00