Integrated Transcriptomics and Experimental Validation Reveal That Ellagic Acid Alleviates Fuchs Endothelial Corneal Dystrophy via PLAU/NF-κB Signaling
These findings demonstrate that EA alleviates oxidative stress and inflammation in FECD by targeting PLAU and regulating NF-κB signaling. This study supports the therapeutic potential of EA and PLAU as a novel intervention for corneal endothelial diseases.
Authors
- Xueyao Cai (ORCID: https://orcid.org/0009-0004-4498-8978)
- Zhou Tj
- Wenjun Shi
- Yuchen Cai
- Xia Ding (ORCID: https://orcid.org/0000-0003-0388-5388)
- Yifan Zhou
- Jiaming Sun
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1167/iovs.67.1.31
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00