Evaluation of cerebrospinal fluid penetration of delafloxacin in a murine model

Cerebrospinal fluid (CSF) penetration of delafloxacin was evaluated in a murine model. Mice received a single 40 mg/kg intraperitoneal dose. Plasma and CSF samples were collected at five time points over 4 h and analyzed by ultra high-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS). Pharmacokinetic parameters, including CSF penetration ratio (AUC<sub>0-4h</sub> CSF/AUC<sub>0-4h</sub> plasma), were determined using a non-compartmental model. The CSF penetration ratio of delafloxacin was 49%. Cmax/MIC ratios met pharmacokinetic/pharmacodynamic targets for <i>Staphylococcus</i> and <i>Streptococcus</i> spp., but not Enterobacterales.

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Journal
Antimicrobial Agents and Chemotherapy
Published
2026-01-14
DOI
https://doi.org/10.1128/aac.01660-25
Primary Topic
Antibiotics Pharmacokinetics and Efficacy
Type
article
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article

Evaluation of cerebrospinal fluid penetration of delafloxacin in a murine model

M. Lahouati, Fabien Xuereb, Vasco Dias Meireles, Antoine Petitcollin et al.
Antimicrobial Agents and Chemotherapy
Antibiotics Pharmacokinetics and Efficacy
article

Evaluation of cerebrospinal fluid penetration of delafloxacin in a murine model

M. Lahouati, Fabien Xuereb, Vasco Dias Meireles, Antoine Petitcollin, Camille Rougnon-Glasson
article en

Abstract

Cerebrospinal fluid (CSF) penetration of delafloxacin was evaluated in a murine model. Mice received a single 40 mg/kg intraperitoneal dose. Plasma and CSF samples were collected at five time points over 4 h and analyzed by ultra high-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS). Pharmacokinetic parameters, including CSF penetration ratio (AUC<sub>0-4h</sub> CSF/AUC<sub>0-4h</sub> plasma), were determined using a non-compartmental model. The CSF penetration ratio of delafloxacin was 49%. Cmax/MIC ratios met pharmacokinetic/pharmacodynamic targets for <i>Staphylococcus</i> and <i>Streptococcus</i> spp., but not Enterobacterales.

Antimicrobial Agents and ChemotherapyVol. 70(2)
Université de Bordeaux (FR), Inserm (FR), Bordeaux Population Health (FR), Biologie Labor (CH), Hôpital Pellegrin (FR)
Openalex Percentile: Top 86%
Antibiotics Pharmacokinetics and Efficacy
DOIOpen Access PDFOpenAlex
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