Glucose dysregulation and glycemic phenotyping in chronic migraine

Chronic migraine subjects exhibited postprandial glucose dysregulation and greater glycemic variability than healthy controls. The identified GTT phenotypes reveal distinct glucose regulation patterns, suggesting the existence of different migraine-associated metabolic profiles. Future research will investigate factors contributing to these phenotypes and their implications for migraine pathogenesis. These findings support the potential for developing targeted migraine treatments informed by glucose dysregulation patterns.

Authors

Publication Details

Journal
Frontiers in Neurology
Published
2026-01-14
DOI
https://doi.org/10.3389/fneur.2025.1719724
Primary Topic
Migraine and Headache Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Glucose dysregulation and glycemic phenotyping in chronic migraine

David Sant, Kyle W. Reavely, Kyle B. Bills, Matthew R. Jennings et al.
Frontiers in Neurology
Migraine and Headache Studies
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Glucose dysregulation and glycemic phenotyping in chronic migraine

David Sant, Kyle W. Reavely, Kyle B. Bills, Matthew R. Jennings, Brandon J. Burger, Christina A. Nelson, Alexander C. Kim
article en

Abstract

Chronic migraine subjects exhibited postprandial glucose dysregulation and greater glycemic variability than healthy controls. The identified GTT phenotypes reveal distinct glucose regulation patterns, suggesting the existence of different migraine-associated metabolic profiles. Future research will investigate factors contributing to these phenotypes and their implications for migraine pathogenesis. These findings support the potential for developing targeted migraine treatments informed by glucose dysregulation patterns.

Frontiers in NeurologyVol. 16
Openalex Percentile: Top 88%
Migraine and Headache Studies
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