Additive Association of ABCG2 rs4148155 and SLC22A12 rs75786299 Polymorphisms with Hyperuricemia, Gout, and Nephrolithiasis: A Hospital-Based, Case-Control Study

The study highlights a significant association between the rs4148155, rs75786299 variants and the development of gout and nephrolithiasis, indicating an additive risk among carriers. These findings support precision healthcare approaches for individuals with risk genetic variants to target hyperuricemia, gout, and systemic comorbidities, ultimately preventing nephrolithiasis.

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Publication Details

Journal
Kidney Diseases
Published
2026-01-14
DOI
https://doi.org/10.1159/000550471
Primary Topic
Gout, Hyperuricemia, Uric Acid
Type
article
Field-Weighted Citation Impact
0.00
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article

Additive Association of ABCG2 rs4148155 and SLC22A12 rs75786299 Polymorphisms with Hyperuricemia, Gout, and Nephrolithiasis: A Hospital-Based, Case-Control Study

Jui‐Chun Chang, Yi-Huei Chen, Jui-Chun Chang, Ching-Heng Lin et al.
Kidney Diseases
Gout, Hyperuricemia, Uric Acid
article

Additive Association of ABCG2 rs4148155 and SLC22A12 rs75786299 Polymorphisms with Hyperuricemia, Gout, and Nephrolithiasis: A Hospital-Based, Case-Control Study

Jui‐Chun Chang, Yi-Huei Chen, Jui-Chun Chang, Ching-Heng Lin, Chia-Yi Wei, Wen-Nan Huang, I-Chieh Chen, Ching-Tsai Lin, Yen-Ju Chen
article en

Abstract

The study highlights a significant association between the rs4148155, rs75786299 variants and the development of gout and nephrolithiasis, indicating an additive risk among carriers. These findings support precision healthcare approaches for individuals with risk genetic variants to target hyperuricemia, gout, and systemic comorbidities, ultimately preventing nephrolithiasis.

Kidney DiseasesVol. 12(1)
Fu Jen Catholic University (TW), National Yang Ming Chiao Tung University (TW), National Chung Hsing University (TW), Tunghai University (TW), China Medical University (TW), National Taipei University of Nursing and Health Science (TW), Taichung Veterans General Hospital (TW), Ministry of Health and Welfare (TW), China Medical University Hospital (TW)
Good health and well-being
Openalex Percentile: Top 89%
Gout, Hyperuricemia, Uric Acid
DOIOpen Access PDFOpenAlex
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