MAF1 loss protects against ischemic cerebral injury by attenuating NLRP3-mediated pyroptosis

MAF1 expression was significantly increased in animal and cellular models of AIS. Knockdown of MAF1 improved neurological function after AIS and the protective effect is related to the regulation of the NLRP3 inflammasome/pyroptosis pathway. These findings elucidated a critical role and mechanistic insight for MAF1 in AIS pathogenesis, highlighting its potential as a therapeutic target for ischemic stroke treatment.