Skin Substitutes: Ushering in a New Era of Transition from Traditional Dressings to Bioprinted Scaffolds

3D bioprinting has revolutionized wound management by addressing the clinical challenges posed by chronic wounds and acute skin defects. While traditional skin substitutes serve critical roles in wound healing, current research focuses on optimizing bioprinting techniques, bioink formulations, and functional biological dressings to enhance tissue regeneration. The field is rapidly advancing through integration with nanotechnology, organoid technology, and microfluidics, while emerging approaches such as AI-assisted, in situ, and 4D bioprinting offer new therapeutic dimensions. This technological evolution necessitates continued innovation to overcome the existing limitations in clinical translation.