Optimal Timing of Surgery Following Neoadjuvant Therapy for Surgical and Oncological Outcomes in Advanced Esophageal Squamous Cell Carcinoma: An Exploratory Analysis of JCOG1109

Time to surgery following neoadjuvant therapy did not significantly influence prognosis in advanced ESCC. Nonetheless, prolonged intervals after chemoradiotherapy may increase surgical complexity and leakage risk, in addition to elevating the potential for adverse prognostic effects associated with excessive delays.

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Publication Details

Journal
Annals of Surgical Oncology
Published
2026-01-14
DOI
https://doi.org/10.1245/s10434-025-19050-6
Primary Topic
Esophageal Cancer Research and Treatment
Type
article
Field-Weighted Citation Impact
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article

Optimal Timing of Surgery Following Neoadjuvant Therapy for Surgical and Oncological Outcomes in Advanced Esophageal Squamous Cell Carcinoma: An Exploratory Analysis of JCOG1109

Keiko Minashi, Tetsuya Abe, Hiroki Hara, Yasue Kimura et al.
Annals of Surgical Oncology
Esophageal Cancer Research and Treatment
article

Optimal Timing of Surgery Following Neoadjuvant Therapy for Surgical and Oncological Outcomes in Advanced Esophageal Squamous Cell Carcinoma: An Exploratory Analysis of JCOG1109

Keiko Minashi, Tetsuya Abe, Hiroki Hara, Yasue Kimura, Ken Kato, Hiroyuki Daiko, Ryunosuke Machida, Hiroya Takeuchi, Takahiro Tsushima, Kazuo Koyanagi, Yoshinori Ito, Ryosuke Kita, Kohei Akiyoshi, Satoru Matsuda, Keita Sasaki, Haruhiko Fukuda, Hirofumi Kawakubo, Kenji Amagai
article en

Abstract

Time to surgery following neoadjuvant therapy did not significantly influence prognosis in advanced ESCC. Nonetheless, prolonged intervals after chemoradiotherapy may increase surgical complexity and leakage risk, in addition to elevating the potential for adverse prognostic effects associated with excessive delays.

Annals of Surgical Oncology
SHOWA Medical University (JP), Tokai University (JP), Keio University (JP), Kyoto University (JP), Hamamatsu University School of Medicine (JP), Shizuoka Cancer Center (JP), National Cancer Center (US), National Hospital Organization Kyushu Cancer Center (JP), Osaka City General Hospital (JP), Chiba Cancer Center (JP), Saitama Cancer Center (JP), Aichi Cancer Center (JP), Ibaraki Prefectural Central Hospital (JP), Japan Clinical Cancer Research Organization (JP)
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Openalex Percentile: Top 88%
Esophageal Cancer Research and Treatment
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Optimal Timing of Surgery Following Neoadjuvant Therapy for Surgical and Oncological Outcomes in Advanced Esophageal Squamous Cell Carcinoma: An Exploratory Analysis of JCOG1109 — Keiko Minashi, Tetsuya Abe, et al. · Annals of Surgical Oncology (2026) | TGRS Research Map | TGRS