Mutational Signatures and Clonal Hematopoiesis in Intestinal Metaplasia across Countries with Varying Stomach Cancer Incidence
This international study identifies recurrent IM driver genes, IM-specific mutational signatures, and alterations in IM-associated immune landscapes and microbiomes. Our results highlight a role for nonepithelial somatic alterations (CH) in IM progression to gastric cancer, offering new translational opportunities for early cancer detection and interception.
Authors
- F. Zhu
- Takeshi Hagihara (ORCID: https://orcid.org/0009-0007-9263-1553)
- P P Tan
- Lee Yi-Chia
- Robert J. Huang (ORCID: https://orcid.org/0000-0002-0891-7409)
- Minghui Lee
- Roxanne Hui Heng Chong
- Benedict Shi Xiang Lian (ORCID: https://orcid.org/0000-0002-3467-5394)
- J. Lee
- A G S TAN
- Siti Aishah Binte Abdul Ghani (ORCID: https://orcid.org/0000-0003-2317-0179)
- Mann Yie Thian
- Wai Leong Tam (ORCID: https://orcid.org/0000-0003-2365-5264)
- Khay Guan Yeoh (ORCID: https://orcid.org/0000-0002-7802-4606)
- Su Ting Tay (ORCID: https://orcid.org/0000-0003-3609-0143)
- Louis Ho Shing Lau (ORCID: https://orcid.org/0000-0002-4163-4531)
- Lin Liu (ORCID: https://orcid.org/0000-0002-0107-5819)
- Xin L. Lu (ORCID: https://orcid.org/0000-0002-6612-8352)
- Clara Shi Ya Ng (ORCID: https://orcid.org/0009-0000-2090-1955)
- Christopher JL Khor
- Hyunsoo CHUNG
- Hei Sunny Wong
- May Yin Lee
- Ruanyi Liang
- Ming Teh
- Zhi Xuan Ong
- Supriya Srivastava
- Kie Kyon Huang
- Shen Kiat Lim
- Shamaine Wei Ting Ho
- Xuewen Ong
- Tiing Leong Ang
- Hui Chen
- Takuji Gotoda
- Jason Xing Kang
- Ayaka Takasu
- Jimmy B.Y. So
- Zhen Li
- Hyun-Soo Kim
Institutions
- Nihon University (JP)
- Agency for Science, Technology and Research (SG)
- National University of Singapore (SG)
- National Taiwan University (TW)
- Singapore Institute of Technology (SG)
- Nanyang Technological University (SG)
- Chinese University of Hong Kong (HK)
- Yonsei University (KR)
- Singapore General Hospital (SG)
- Changi General Hospital (SG)
- Tan Tock Seng Hospital (SG)
- New Generation University College (ET)
- National University Cancer Institute, Singapore (SG)
- Ludwig Cancer Research (GB)
- Duke-NUS Medical School (SG)
- National Cancer Centre Singapore (SG)
- Stanford Medicine (US)
- National University Hospital (SG)
- National Heart Centre Singapore (SG)
- Japanese Foundation For Cancer Research (JP)
- Stanford University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-0778
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00