Synthesis of 2-Thioxo-1,3-benzothiazin-4-one by PPh <sub>3</sub> -Promoted Desulfurative [4 + 2] Annulation
An efficient construction of 2-thioxo-1,3-benzothiazin-4-ones has been developed via a PPh<sub>3</sub>-promoted desulfurative [4 + 2] annulation between benzo[<i>c</i>][1,2]dithiol-3-ones and isothiocyanates. This strategy is characterized by its mild reaction conditions, operational simplicity, excellent yields, wide functional group tolerance, accessible scalability, and practical transformations.
Authors
- Chuan‐Chuan Wang
- MENG-RU REN
- Q. H. Wang
- Yajing Chen (ORCID: https://orcid.org/0000-0002-0362-7138)
- Hong Zhang
- Yao-Jie Xue
- Shu-Yan Wu
Institutions
- Zhongyuan University of Technology (CN)
- Zhengzhou University (CN)
- Zhengzhou University of Science and Technology (CN)
- Henan Agricultural University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1021/acs.joc.5c02876
- Citations
- 1
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 22.95