Review of Polymers and Nanocomposites Based on Hyaluronic Acid and Zinc Oxide Nanoparticles in Synthesizing Microneedles for Transdermal Drug Delivery

The objective of this review is to provide an in-depth overview of the current state of research on microneedles for drug delivery, with emphasis on composite systems, particularly those based on hyaluronic acid (HA) and zinc oxide as composite systems. The review discusses the advantages, challenges, and future directions associated with the use of these materials for microneedle-based drug delivery. Hyaluronic acid, which is naturally found in human tissue, has been shown to enhance drug permeation and improve skin hydration, while ZnO has provided high mechanical durability and prevented microbial and bacterial growth. The use of dissolvable microneedles is a viable substitute for traditional drug delivery methods such as oral or intravenous administration. Ongoing research is being conducted to further improve the performance, safety, and effectiveness of microneedles for various drug delivery applications.