Glucagon-like peptide-1 receptor agonists for obesity: Growing popularity met with growing questions over safety

Glucagon-like peptide-1 (GLP-1)-based medications, such as semaglutide and tirzepatide, have transformed obesity care. However, rising use brings concerns about side effects, long-term outcomes, and unregulated products. Ensuring safe access requires oversight, monitoring, and coordinated clinical care.

Authors

Ariana M. Chao (ORCID: https://orcid.org/0000-0001-5633-8973)
Adam H. Gilden (ORCID: https://orcid.org/0000-0001-9451-021X)
Thomas A. Wadden

Institutions

Johns Hopkins University (US)
Johns Hopkins Medicine (US)
University of Pennsylvania (US)
University of Colorado Denver (US)

Publication Details

Journal: PLoS Medicine
Published: 2026-01-14
DOI: https://doi.org/10.1371/journal.pmed.1004871
Citations: 1
Primary Topic: Diabetes Treatment and Management
Type: article
Field-Weighted Citation Impact: 30.73

Controls

|||

ALL TIME

JAN

FEB

MAR

APR

MAY

JUN

JUL

AUG

SEP

OCT

article

Glucagon-like peptide-1 receptor agonists for obesity: Growing popularity met with growing questions over safety

Ariana M. Chao, Adam H. Gilden, Thomas A. Wadden

Jan 14, 2026

1 citations

PLoS Medicine

Diabetes Treatment and Management

30.73

article

Glucagon-like peptide-1 receptor agonists for obesity: Growing popularity met with growing questions over safety

Ariana M. Chao, Adam H. Gilden, Thomas A. Wadden

January 14, 2026article en

1 citations

Abstract

PLoS MedicineVol. 23(1)

Johns Hopkins University (US), Johns Hopkins Medicine (US), University of Pennsylvania (US), University of Colorado Denver (US)

Good health and well-being

Openalex Percentile: Top 2%

Diabetes Treatment and Management

30.73

DOI Open Access PDF OpenAlex

AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Glucagon-like peptide-1 receptor agonists for obesity: Growing popularity met with growing questions over safety — Ariana M. Chao, Adam H. Gilden, et al. · PLoS Medicine (2026) | TGRS Research Map | TGRS