O-GlcNAcylation of NONO mediates alternative splicing of SETMAR and facilitates NHEJ repair
O-GlcNAcylation at Ser 147 of NONO mediates the alternative splicing of SETMAR and facilitates NHEJ repair. Collectively, our findings suggest that targeting NONO O-GlcNAcylation may provide a novel therapeutic strategy for cancer treatment.
Authors
- Xin Guo (ORCID: https://orcid.org/0000-0001-9880-6835)
- Chen Wu (ORCID: https://orcid.org/0000-0002-2791-7172)
- Hongbing Zhang (ORCID: https://orcid.org/0000-0003-3864-7152)
- Hui Li (ORCID: https://orcid.org/0000-0003-0075-2125)
- Ziyi Zhou (ORCID: https://orcid.org/0009-0006-7034-9808)
- Yajie Jiao
- Yuhan Jiang
- Weijie Qin
- Shuai Guo
- Huanna Tian
Institutions
- Beijing Proteome Research Center (CN)
- Hebei University (CN)
Publication Details
- Journal
- Genome biology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1186/s13059-026-03930-5
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00