Outside Front Cover: Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters (Angew. Chem. Int. Ed. 8/2026)
In their Research Article (e19203), Darrell J. Irvine, Paula T. Hammond, and co-workers uncover that the dense presentation of anionic amino-acid motifs on layer-by-layer nanoparticles (green) enables selective recognition of amino-acid transporters on cancer cells (pink; blue nucleus; white indicates NP–receptor colocalization). These findings define a transporter-targeting mode of action for a nanoparticle delivery platform with demonstrated preclinical activity.
Authors
- Aidan Kindopp (ORCID: https://orcid.org/0009-0002-7560-8611)
- Ezra Gordon (ORCID: https://orcid.org/0009-0002-6023-2789)
- Mae L. Pryor (ORCID: https://orcid.org/0000-0002-7211-8150)
- Alexander D. Stoneman (ORCID: https://orcid.org/0000-0002-5662-6542)
- Margaret M. Billingsley (ORCID: https://orcid.org/0000-0003-4499-9066)
- Eva Cai
- Gonzalo J. Esparza
- Paula T. Hammond
- Ivan S. Pires
- Darrell J. Irvine
- Andrew J. Pickering
Institutions
- Howard Hughes Medical Institute (US)
- Ragon Institute of MGH, MIT and Harvard (US)
- Harvard–MIT Division of Health Sciences and Technology (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1002/anie.2026-m1001093800
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00