Utility of Fluorescence In Situ Hybridization as a Fetal Surgery Eligibility Criterion for Isolated Congenital Anomalies When Non‐Invasive Screening Is Performed

In this study cohort, FISH did not provide additional information for the risk-benefit analysis of fetal surgery and introduced additional risk to the pregnancy due to the need for invasive fetal DNA collection.

Authors

Kara B. Markham (ORCID: https://orcid.org/0009-0006-3523-1935)
Beatrix Wong (ORCID: https://orcid.org/0000-0001-9307-724X)
Katelyn Seither (ORCID: https://orcid.org/0000-0002-8204-7667)
Hua He (ORCID: https://orcid.org/0009-0003-2585-7684)
Ethan Lorence

Institutions

Cincinnati Children's Hospital Medical Center (US)
TriHealth (US)
University of Cincinnati Medical Center (US)

Publication Details

Journal: Prenatal Diagnosis
Published: 2026-01-14
DOI: https://doi.org/10.1002/pd.70068
Primary Topic: Prenatal Screening and Diagnostics
Type: article
Field-Weighted Citation Impact: 0.00

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article

Utility of Fluorescence In Situ Hybridization as a Fetal Surgery Eligibility Criterion for Isolated Congenital Anomalies When Non‐Invasive Screening Is Performed

Kara B. Markham, Beatrix Wong, Katelyn Seither, Hua He et al.

Jan 14, 2026

Prenatal Diagnosis

Prenatal Screening and Diagnostics

article

Utility of Fluorescence In Situ Hybridization as a Fetal Surgery Eligibility Criterion for Isolated Congenital Anomalies When Non‐Invasive Screening Is Performed

Kara B. Markham, Beatrix Wong, Katelyn Seither, Hua He, Ethan Lorence

January 14, 2026article en

Abstract

In this study cohort, FISH did not provide additional information for the risk-benefit analysis of fetal surgery and introduced additional risk to the pregnancy due to the need for invasive fetal DNA collection.

Prenatal DiagnosisVol. 46(2)

Cincinnati Children's Hospital Medical Center (US), TriHealth (US), University of Cincinnati Medical Center (US)

Openalex Percentile: Top 88%

Prenatal Screening and Diagnostics

DOI Source OpenAlex

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