Site-Specific Blockade of LPA–TRPV1 Interaction at K710 Residue Influences on Myocardial Ischemia/Reperfusion Injury in Ex Vivo Mouse Hearts

Blockade of the TRPV1 K710 site by K710N mutation or V1-Cal peptide mitigates LPA-mediated myocardial injury and mitochondrial damage/dysfunction in isolated mouse hearts. Targeting the cardiac LPA-TRPV1 interaction represents a promising therapeutic strategy against perioperative myocardial injury.

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Publication Details

Journal
Anesthesia & Analgesia
Published
2026-01-14
DOI
https://doi.org/10.1213/ane.0000000000007907
Primary Topic
Ion Channels and Receptors
Type
article
Field-Weighted Citation Impact
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article

Site-Specific Blockade of LPA–TRPV1 Interaction at K710 Residue Influences on Myocardial Ischemia/Reperfusion Injury in Ex Vivo Mouse Hearts

Muge Qile, Eric R. Gross, Zhaofei Luo, Ye Zhang et al.
Anesthesia & Analgesia
Ion Channels and Receptors
article

Site-Specific Blockade of LPA–TRPV1 Interaction at K710 Residue Influences on Myocardial Ischemia/Reperfusion Injury in Ex Vivo Mouse Hearts

Muge Qile, Eric R. Gross, Zhaofei Luo, Ye Zhang, Chao Wu, Shufang He, Qingtong Wang, Yu Zhang, Liu Liu, Xueying Cheng
article en

Abstract

Blockade of the TRPV1 K710 site by K710N mutation or V1-Cal peptide mitigates LPA-mediated myocardial injury and mitochondrial damage/dysfunction in isolated mouse hearts. Targeting the cardiac LPA-TRPV1 interaction represents a promising therapeutic strategy against perioperative myocardial injury.

Anesthesia & Analgesia
Anhui Medical University (CN), Nanjing Drum Tower Hospital (CN), Stanford Medicine (US), Second Affiliated Hospital of Anhui Medical University (CN), Ministry of Education (KN), Stanford University (US)
Good health and well-being
Openalex Percentile: Top 88%
Ion Channels and Receptors
DOISourceOpenAlex
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Site-Specific Blockade of LPA–TRPV1 Interaction at K710 Residue Influences on Myocardial Ischemia/Reperfusion Injury in Ex Vivo Mouse Hearts — Muge Qile, Eric R. Gross, et al. · Anesthesia & Analgesia (2026) | TGRS Research Map | TGRS