Plasma biomarkers predict incident cognitive decline up to 29 years prior to disease onset: a memory clinic cohort study of 4,073 participants
Leveraging a large cohort with extensive longitudinal data, our findings underscore the significant value of blood-based biomarkers in predicting cognitive decline to aid personalized clinical management and ultimately improve patient outcomes.
Authors
- Julia Kofler (ORCID: https://orcid.org/0000-0003-4298-7328)
- Miloš D. Ikonomović (ORCID: https://orcid.org/0000-0002-8745-3293)
- OL Lopez
- R. D. Sweet
- Alexandra Gogola (ORCID: https://orcid.org/0000-0002-8798-1715)
- Margaret A Bedison
- Rebecca A. Deek (ORCID: https://orcid.org/0000-0002-8783-4694)
- Jeremy Gu
- Tara K Lafferty
- Lamia Choity
- Michel N Nafash
- Rocco B Mercurio
- Sarah B Berman
- Cristy Matan
- Jennifer H Lingler
- Ann D Cohen
- Dana L Tudorascu
- Xuemei Zeng
- Thomas K Karikari
- William E Klunk
- M. Ilyas Kamboh
- Beth E. Snitz
- Marissa F Farinas
- Victor L. Villemagne
- C. Elizabeth Shaaban
Institutions
- University of Pittsburgh (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_106702
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00