Adverse Events After Metastases-Directed Stereotactic Radiotherapy and Biological Cancer Therapy
In this cohort study of 433 patients, severe adverse events after SRT and concurrent BCT were uncommon (<10%), continuing BCT during SRT was not associated with increased risk of severe adverse events, and interrupting BCT was not associated with worse OS when correcting for patients' performance status. These findings suggest a favorable safety profile of metastases-directed SBRT in combined modality treatment settings.
Authors
- S. Siva
- Famke L. Schneiders (ORCID: https://orcid.org/0000-0002-5204-1774)
- Susanne Rogers (ORCID: https://orcid.org/0000-0003-0094-1890)
- Andrea Wittig
- Susanne Stera
- Franziska Eckert (ORCID: https://orcid.org/0000-0002-4742-3962)
- Fabian Lohaus (ORCID: https://orcid.org/0000-0003-4043-7066)
- Mathieu Spaas
- Ilinca Popp (ORCID: https://orcid.org/0000-0001-6702-3619)
- Jana Schaule (ORCID: https://orcid.org/0000-0001-5870-0980)
- Markus Schymalla
- David Kaul
- Sergi Benavente (ORCID: https://orcid.org/0000-0002-2700-3522)
- Esmée L. Looman (ORCID: https://orcid.org/0000-0002-0026-0553)
- Victor Lewitzki (ORCID: https://orcid.org/0000-0001-9146-3083)
- Kynann P. Aninditha (ORCID: https://orcid.org/0009-0001-4651-5558)
- Uhlmann
- Hans Geinitz
- Katrien De Jaeger
- Oliver Blanck
- Friederike L A Koppe
- Joost J C Verhoeff
- Matthias Guckenberger
- Georgios Skazikis
- Stephanie G. C. Kroeze
- Stephanie E. Combs
Institutions
- Goethe University Frankfurt (DE)
- Johannes Kepler University of Linz (AT)
- Hebron University (PS)
- Radboud University Nijmegen (NL)
- Philipps University of Marburg (DE)
- University of Potsdam (DE)
- University of Zurich (CH)
- Peter MacCallum Cancer Centre (AU)
- University of Applied Sciences Potsdam (DE)
- Ghent University Hospital (BE)
- Catharina Ziekenhuis (NL)
- University Medical Center Freiburg (DE)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- University Hospital Augsburg (DE)
- University Medical Center Utrecht (NL)
- University Hospital of Zurich (CH)
- University Hospital Schleswig-Holstein (DE)
- Kepler Universitätsklinikum (AT)
- University Children's Hospital Tübingen (DE)
- Universitätsklinikum Würzburg (DE)
- Vall d'Hebron Hospital Universitari (ES)
- Instituut Verbeeten (NL)
- University Hospital Frankfurt (DE)
- Jena University Hospital (DE)
- Schwarzwald-Baar Klinikum (DE)
- AGO Austria (AT)
- Amsterdam University Medical Centers (NL)
- Kantonsspital Aarau (CH)
- Klinikum Stuttgart (DE)
- University Hospital Carl Gustav Carus (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Technical University of Munich (DE)
- Medical University of Vienna (AT)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Vrije Universiteit Amsterdam (NL)
- University of Lübeck (DE)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.53809
- Citations
- 1
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 36.44