Migration and invasion inhibitory protein inhibits M2 macrophage polarization to suppress colorectal cancer progression through the STING–NFκB2–IL10 axis
This study established MIIP as a crucial regulator of macrophage polarization in the CRC tumor microenvironment, providing new insights into the role in suppressing CRC progression and immune-tumor crosstalk. These findings highlight the potential of targeting the STING pathway as a therapeutic strategy for CRC patients who respond poorly to immune checkpoint inhibitors.
Authors
- Chenglu Lu (ORCID: https://orcid.org/0000-0002-5198-0016)
- Jiaxin Li (ORCID: https://orcid.org/0009-0001-0602-2230)
- Shuai Chen
- Yan Sun
- Xilin Shen
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Tangshan People's Hospital (CN)
- Affiliated Hospital of Jining Medical University (CN)
Publication Details
- Journal
- Cancer Biology and Medicine
- Published
- 2026-01-14
- DOI
- https://doi.org/10.20892/j.issn.2095-3941.2025.0282
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City
- Jining Medical University