Jujuboside A induces bladder cancer cell apoptosis by inhibiting ATP1A2-mediated mitochondrial energy metabolism regulation

This study elucidated the molecular mechanism by which JuA regulates mitochondrial energy metabolism and induces apoptosis in bladder cancer cells through targeted inhibition of ATP1A2. These findings reveal the crucial role of ATP1A2 in the energy metabolism and survival of bladder cancer cells, providing a new molecular perspective for a deeper understanding of the pathological mechanisms of bladder cancer.

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Publication Details

Journal
Cancer Biology & Therapy
Published
2026-01-14
DOI
https://doi.org/10.1080/15384047.2026.2615418
Primary Topic
Ziziphus Jujuba Studies and Applications
Type
article
Field-Weighted Citation Impact
0.00
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article

Jujuboside A induces bladder cancer cell apoptosis by inhibiting ATP1A2-mediated mitochondrial energy metabolism regulation

Mengqing Zhu, Lixin Ren, Yaxuan Wang, Yumin Jia et al.
Cancer Biology & Therapy
Ziziphus Jujuba Studies and Applications
article

Jujuboside A induces bladder cancer cell apoptosis by inhibiting ATP1A2-mediated mitochondrial energy metabolism regulation

Mengqing Zhu, Lixin Ren, Yaxuan Wang, Yumin Jia, Yuepeng Liu, Shuhui An
article en

Abstract

This study elucidated the molecular mechanism by which JuA regulates mitochondrial energy metabolism and induces apoptosis in bladder cancer cells through targeted inhibition of ATP1A2. These findings reveal the crucial role of ATP1A2 in the energy metabolism and survival of bladder cancer cells, providing a new molecular perspective for a deeper understanding of the pathological mechanisms of bladder cancer.

Cancer Biology & TherapyVol. 27(1)
Hebei Medical University (CN), Second Hospital of Hebei Medical University (CN)
Affordable and clean energy
Openalex Percentile: Top 88%
Ziziphus Jujuba Studies and Applications
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