Serum and Urinary Metabolomics Reflect the Early Stages of De Novo Metabolic Syndrome After Liver Transplant: A 2-Center Longitudinal Study
LT is followed by distinct metabolic shifts reflecting changes in both hepatic lipid metabolism and gut-liver microbial cometabolism. Elevated urinary TMAO, together with reduced serum phosphocholine and lipid-CH 3 responses, characterize patients who develop post-LT MetS and may serve as early biomarkers of cardiometabolic risk in LT recipients.
Authors
- Andrew Fagan
- Thresiamma Lukose
- Elizabeth C. Verna (ORCID: https://orcid.org/0000-0002-9658-3751)
- Jasmohan Singh Bajaj (ORCID: https://orcid.org/0000-0003-4928-3681)
- Mette Munk Lauridsen
- Adrien Le Guennec
- Geena G. Heitmann
- I. Jane Cox
Institutions
- King's College London (GB)
- Columbia University Irving Medical Center (US)
- Foundation for Liver Research (GB)
- Virginia Commonwealth University Medical Center (US)
Publication Details
- Journal
- Clinical and Translational Gastroenterology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.14309/ctg.0000000000000968
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00