The association between DNA repair genes polymorphisms and cisplatin-induced ototoxicity in cancer patients: a systematic review

Although several DNA repair gene polymorphisms have been explored, findings remain inconsistent and limited by populations and SNPs studied. Larger, well-designed studies with standardized methodologies are needed to confirm these associations and identify genetic markers for predicting high-risk patients for CIO.

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Publication Details

Journal
Personalized Medicine
Published
2025-11-02
DOI
https://doi.org/10.1080/17410541.2025.2607150
Primary Topic
Hearing, Cochlea, Tinnitus, Genetics
Type
article
Field-Weighted Citation Impact
0.00
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article

The association between DNA repair genes polymorphisms and cisplatin-induced ototoxicity in cancer patients: a systematic review

Hazem Elewa, S. Said, Rana Mekkawi, Anas Hamad et al.
Personalized Medicine
Hearing, Cochlea, Tinnitus, Genetics
article

The association between DNA repair genes polymorphisms and cisplatin-induced ototoxicity in cancer patients: a systematic review

Hazem Elewa, S. Said, Rana Mekkawi, Anas Hamad, Fatima Hawasly, Nabil E. Omar, Omar Abd Elrahman
article en

Abstract

Although several DNA repair gene polymorphisms have been explored, findings remain inconsistent and limited by populations and SNPs studied. Larger, well-designed studies with standardized methodologies are needed to confirm these associations and identify genetic markers for predicting high-risk patients for CIO.

Personalized MedicineVol. 22(6)
National Center for Cancer Care and Research (QA), Hamad Medical Corporation (QA), Qatar University (QA)
Good health and well-being
Openalex Percentile: Top 30%
Hearing, Cochlea, Tinnitus, Genetics
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