Targeting CDK11 in Rhabdoid Tumor of the Kidney
CDK11 inhibition by OTS964 effectively suppresses RTK growth through cell cycle arrest and RNA splicing inhibition, leading to apoptosis. OTS964 shows potent anti-tumor activity and tolerability, supporting CDK11 as a promising therapeutic target for RTK and related <i>SMARCB1</i>-deficient cancers.
Authors
- Kenneth A. Iczkowski (ORCID: https://orcid.org/0000-0002-8909-8811)
- Elizabeth Helmke (ORCID: https://orcid.org/0000-0002-2981-1523)
- Noriko Satake (ORCID: https://orcid.org/0000-0002-8713-2529)
- K Lam
- Yueju Li
- Shinsuke Fukui
- Yuki Murakami
Institutions
- University of California, Davis (US)
Publication Details
- Journal
- Cancers
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3390/cancers18020261
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Research Coordinating Committee
- University of California, Davis
- Japan Society for the Promotion of Science