Tumour immune contexture and immune evasion in sporadic and Lynch syndrome-associated microsatellite unstable colorectal cancers
Our findings reveal differences between sporadic MSI and LS tumours in T cell and myeloid immune cell landscapes, and in immune evasion. These differences may contribute to the variable immunotherapy responses among MSI CRC patients and are targetable by emerging therapeutic approaches.
Authors
- Maarit Ahtiainen (ORCID: https://orcid.org/0000-0002-3263-2307)
- Hanna Elomaa (ORCID: https://orcid.org/0000-0002-5378-7703)
- A. Ristimäki
- Erkki‐Ville Wirta (ORCID: https://orcid.org/0000-0002-2255-6136)
- Laura Renkonen‐Sinisalo (ORCID: https://orcid.org/0000-0002-3122-5312)
- Kyösti Tahkola (ORCID: https://orcid.org/0000-0002-1626-5690)
- Selja Koskensalo (ORCID: https://orcid.org/0000-0001-6959-8715)
- Juha P. Väyrynen (ORCID: https://orcid.org/0000-0002-8683-2996)
- Samantha Martin (ORCID: https://orcid.org/0009-0009-8673-7583)
- Kristiina Rajamäki (ORCID: https://orcid.org/0000-0001-5151-1220)
- Jukka-Pekka Mecklin
- Toni T. Seppälä
- Jan Böhm
- Kimmo Palin
- Anna Lepistö
- Lauri A. Aaltonen
Institutions
- University of Helsinki (FI)
- Oulu University Hospital (FI)
- Helsinki University Hospital (FI)
- Wihuri Research Institute (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Central Finland Health Care District (FI)
- Hospital District of Helsinki and Uusimaa (FI)
- University of Jyväskylä (FI)
- University of Oulu (FI)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1038/s41416-025-03302-z
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Helsingin Yliopisto
- Helsingin ja Uudenmaan Sairaanhoitopiiri
- Jane ja Aatos Erkon Säätiö
- China Scholarship Council
- Sigrid Juséliuksen Säätiö
- Syöpäsäätiö
- Helsinki Institute of Life Science, Helsingin Yliopisto