Investigation of the skin recovery dynamics following acute sleep deprivation and the correlations among biological parameters

Abstract Background Sleep deprivation leads to changes in circadian rhythm, causing skin problems and aging. Whether acute sleep deprivation can be normalized after 14 days of natural skin metabolism is an important indicator for guiding treatment of sleep‐related skin physiological changes and mechanisms. Methods This study aims to investigate skin biophysical changes after one night of acute sleep deprivation and to assess a 14‐day post‐sleep deprivation recovery period to understand the most relevant skin biophysical changes correlated with circadian rhythm disruption. Forty‐four Chinese women aged 21–49 participated in a single‐center, self‐controlled study in Beijing, China. Results After one night of sleep deprivation, their 14‐day recovery status was observed using a variety of skin physiological parameters. We found that the impacts of sleep deprivation on skin condition could not be fully recovered. Key correlations were identified, such as between skin lightness and pigmentation intensity. Skin transparency was more closely associated with hydration, yellowness and redness. Conclusion These insights provide a foundation for further research into the long‐term impacts of sleep deprivation on skin health and the development of innovative assessment and intervention methods. The machine learning model has the potential to be integrated into portable devices for real‐time skin health monitoring, enabling more personalized and effective skin care strategies.