Retinal Amyloid Clearance Enhanced by 40-Hz Light Flicker via MHC-II <sup>+</sup> Microglia Regulation in Mice
We observed that 40-Hz light flicker enhances retinal microglial clearance of Aβ oligomers by upregulating MHC-II expression. These findings support 40-Hz light flicker as a non-invasive therapeutic strategy for age-related retinal disorders by promoting metabolic waste clearance.
Authors
- Shibo Tang
- Yinhua Huang (ORCID: https://orcid.org/0000-0001-9875-000X)
- Jiansu Chen
- Chengcheng Ding
- Jianing Gu
- Xiaobo Xia
- Zekai Cui
- Qichang Wang
- Wang Sheng
Institutions
- Twitter (United States) (US)
- Central South University (CN)
- Jinan University (CN)
- He Eye Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1167/iovs.67.1.32
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00