Identifying metabolic bottlenecks for micafungin precursor production via untargeted regulatory perturbation
This work elucidates the metabolic network governing FR901379 biosynthesis and provides key candidates for further metabolic engineering. It also demonstrates that untargeted regulatory perturbation strategy is an effective approach for deciphering the mechanisms behind specific phenotypic traits in industrial filamentous fungi.
Authors
- Ping Men
- Yu Zhou (ORCID: https://orcid.org/0000-0001-9331-9480)
- Hu S
- Yanping Li
- Xuenian Huang
- Li Xie
- Xuefeng Lu
Institutions
- Nanchang University (CN)
- Qingdao Agricultural University (CN)
- Chinese Academy of Sciences (CN)
- University of Jinan (CN)
- Qingdao National Laboratory for Marine Science and Technology (CN)
- Qinghai New Energy (China) (CN)
- State Key Laboratory of Food Science and Technology (CN)
- Qingdao Huanghai University (CN)
- Qingdao Institute of Bioenergy and Bioprocess Technology (CN)
- Qingdao Center of Resource Chemistry and New Materials (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Biotechnology for Biofuels and Bioproducts
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1186/s13068-026-02737-7
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00