Association of vaginal IL-4, IL-6, IL-8, IL-17, IFN-γ, and dietary intake with IBD status and vaginal microbiota in pregnant individuals
The vaginal microbiome did not differ between individuals with IBD and HC; however, IBD cases exhibit a pro-inflammatory tone in the vagina (high IL-6) that is associated with higher vaginal microbial diversity. Regardless of IBD status, healthier diets are positively associated with an increased abundance of the beneficial L. crispatus in the vagina.
Authors
- Camilla Madziar
- Heidi K. Leftwich (ORCID: https://orcid.org/0000-0002-8825-9249)
- Daniela Vargas-Robles (ORCID: https://orcid.org/0000-0001-5178-6478)
- Mayra Rojas-Correa
- Doyle V. Ward (ORCID: https://orcid.org/0000-0002-4952-824X)
- Christine Frisard (ORCID: https://orcid.org/0000-0002-7104-7821)
- Yan Rou Yap
- Tina Dumont
- Barbara C. Olendzki (ORCID: https://orcid.org/0000-0003-4307-5187)
- Mallika Purandare
- Joyce Tien
- Mellissa Picker
- Ana Maldonado-Contreras
- Biplab Singha
- Inga Peter
Institutions
- University of Massachusetts Chan Medical School (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1371/journal.pone.0335178
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00