Evaluation of lncRNA PVT1 rs13255292 variant and serum E-cadherin levels in breast cancer

The current finding underscores that the CC genotype is associated with less aggressive luminal A tumors. It also reveals an inverse link between tumor grade and E-cadherin serum levels. These findings suggest that combining genetic screening of PVT1 variants with E-cadherin surveillance could enhance prognostic stratification in BC management. Further validation in larger cohorts is required to confirm clinical utility.