Differential working memory changes following methylphenidate in medication‐naive and medication‐experienced adults with ADHD
Two groups showed differential trajectories of change in the SWM task. Rather than reflecting a purely pharmacological effect, these patterns may involve a combination of baseline cognitive differences, learned cognitive strategies, and pre-existing individual characteristics. These preliminary findings highlight the importance of considering treatment history in clinical practice and research.
Authors
- Hidehiko Takahashi (ORCID: https://orcid.org/0000-0002-5102-1982)
- Hironobu Nakamura (ORCID: https://orcid.org/0000-0002-1082-7533)
- Yumi Shikauchi (ORCID: https://orcid.org/0000-0001-5732-9833)
- Takashi Itahashi (ORCID: https://orcid.org/0000-0001-7606-7090)
- Genichi Sugihara
- Masaaki Shimizu
- Motoaki Nakamura
- Shunsuke Takagi
- Ryuta Aoki
Institutions
- SHOWA Medical University (JP)
- Tokyo Medical and Dental University (JP)
- Waseda University (JP)
- Kyoto University (JP)
- RIKEN Center for Brain Science (JP)
- Institute of Science Tokyo (JP)
- Tokyo Metropolitan University (JP)
Publication Details
- Journal
- Psychiatry and Clinical Neurosciences Reports
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1002/pcn5.70286
- Primary Topic
- Attention Deficit Hyperactivity Disorder
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Core Research for Evolutional Science and Technology
- Moonshot Research and Development Program