Determinants of survival after re-resection for recurrent glioblastoma: a meta-analysis
Our findings suggest gross total resection of contrast-enhancing tumour and MGMT promoter methylation are strongly associated with improved survival following first recurrence of glioblastoma. Conversely, age, preoperative KPS, adjuvant chemotherapy, and timing of re-resection showed inconsistent or non-significant associations, emphasizing the need for prospective studies to refine prognostic assessments and guide individualized treatment strategies in recurrent glioblastoma.
Authors
- Dragan Janković (ORCID: https://orcid.org/0000-0003-1198-0174)
- Hariharan Subbiah Ponniah (ORCID: https://orcid.org/0000-0002-5471-9120)
- Santhosh G. Thavarajasingam (ORCID: https://orcid.org/0000-0002-9274-0350)
- Ahkash Thavarajasingam
- A. Krämer
- Darius Kalasauskas (ORCID: https://orcid.org/0000-0001-6174-3949)
- Veit Stöcklein
- Srikar R. Namireddy (ORCID: https://orcid.org/0000-0001-5660-4039)
- Daniele Ramsay (ORCID: https://orcid.org/0000-0002-6247-8398)
- Melvin Baby
- Daniel Scurtu
- Rithvik Mahadev Narendranath
- Ahmed Salih
- Symriti Kaur-Paneser
- Florian Ringel
Institutions
- Johannes Gutenberg University Mainz (DE)
- LMU Klinikum (DE)
- Medizinische Hochschule Hannover (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Imperial College London (GB)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Acta Neurochirurgica
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1007/s00701-025-06755-6
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00