Assessing the relationship between gout and the risk of cataract in community-dwelling older adults: mediation and moderation analysis
This cohort study found that gout was an independent risk factor for cataract, with a significant impact on senile cataract. GCC use modified the effect of gout on the development of senile cataract (interaction effect), thus prescribing GCC to patients with gout should be actively monitored for cataract development.
Authors
- Yanlei Chen (ORCID: https://orcid.org/0000-0002-9017-6506)
- Xianwen Shang (ORCID: https://orcid.org/0000-0001-6143-9349)
- Xueli Zhang (ORCID: https://orcid.org/0000-0001-5963-9261)
- Shuilian Chen (ORCID: https://orcid.org/0009-0005-9532-4730)
- Y. Waterlily Huang (ORCID: https://orcid.org/0000-0001-5838-7656)
- Chunxin Lai (ORCID: https://orcid.org/0009-0008-8293-1111)
- Fulong Luo
- Zhuoting Zhu
- Yongyi Niu
- Yongjie Qin
- Hongyang Zhang
Institutions
- Ninewells Hospital (GB)
- Shantou University (CN)
- Centre for Eye Research Australia (AU)
- Shantou University Medical College (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fmed.2025.1740517
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Guangdong Provincial People's Hospital