Altered acetate metabolism and signaling in IgA nephropathy: an integrated gut microbiome and glomerular spatial transcriptome analysis
IgAN is characterized by gut microbial enrichment in acetate metabolism and increased systemic acetate levels, along with altered intraglomerular expression of metabolic and signaling genes. These findings suggest a gut microbiome-glomerular signaling axis contributing to disease pathogenesis.
Authors
- S. Park
- Jung Hun Koh (ORCID: https://orcid.org/0000-0001-7373-5487)
- Hoonsik Nam (ORCID: https://orcid.org/0000-0003-2248-6833)
- Doyeon Kim (ORCID: https://orcid.org/0000-0002-9215-7296)
- Jangwook Lee (ORCID: https://orcid.org/0000-0001-7595-5192)
- Hyun Je Kim
- Minshu Li (ORCID: https://orcid.org/0000-0003-1321-7893)
- Hyunjeong Cho
- Ji In Park
- Yon Su Kim
- Sunghyouk Park
- Kyung Chul Moon
- Hajeong Lee
- Dong Ki Kim
- Ji Eun Kim
Institutions
- Seoul National University (KR)
- Korea University Medical Center (KR)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- Dongguk University Ilsan Hospital (KR)
- Kangwon National University Hospital (KR)
- Chungbuk National University Hospital (KR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1665585
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Seoul National University
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Seoul National University Hospital