The role of bronchoalveolar lavage fluid metagenomic next-generation sequencing in detecting pathogens and optimising antibiotic therapy in paediatric severe community-acquired pneumonia
Metagenomic next-generation sequencing outperforms CMT in pathogen detection. Early mNGS is associated with improved clinical outcomes, suggesting its potential utility in paediatric SCAP management.
Authors
- Duoduo Li (ORCID: https://orcid.org/0009-0004-5629-4471)
- Xiangtao Wu (ORCID: https://orcid.org/0000-0002-2277-9612)
- Shujun Li (ORCID: https://orcid.org/0009-0000-9153-5323)
- Yanyan Ma (ORCID: https://orcid.org/0000-0003-2847-3726)
- Weihong Lu
- Yishuai Ren
- Xixia Guo
- Qian Huang
- Luyang Guo
- Yali Xu
Institutions
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fcimb.2025.1688473
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00