Dose-Volume Predictors of Fatal Bronchopulmonary Bleeding After Stereotactic Body Radiation Therapy of Centrally Located Lung Tumors: An Analysis of the Expanded HILUS Cohort

Bronchial tumor compression is a strong predictor for grade-5 bleeding, and the most relevant dose parameter appears to be the dose to a small volume of the main and intermediate bronchi.

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Publication Details

Journal
International Journal of Radiation Oncology*Biology*Physics
Published
2026-01-14
DOI
https://doi.org/10.1016/j.ijrobp.2025.12.007
Primary Topic
Lung Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

Dose-Volume Predictors of Fatal Bronchopulmonary Bleeding After Stereotactic Body Radiation Therapy of Centrally Located Lung Tumors: An Analysis of the Expanded HILUS Cohort

Britta Lödén, Marianne Marquard Knap, Ditte Sloth Møller, Ingmar Lax et al.
International Journal of Radiation Oncology*Biology*Physics
Lung Cancer Diagnosis and Treatment
article

Dose-Volume Predictors of Fatal Bronchopulmonary Bleeding After Stereotactic Body Radiation Therapy of Centrally Located Lung Tumors: An Analysis of the Expanded HILUS Cohort

Britta Lödén, Marianne Marquard Knap, Ditte Sloth Møller, Ingmar Lax, Vitali Grozman, Per Bergström, Ninni Drugge, Charlotte Kristiansen, Hans-Olov Rosenbrand, Elias Lindbäck, Lotte Rogg, Gitte Fredberg Persson, Silke Engelholm, Charlotte Billiet, Karin Lindberg, Sara Lindberg, Eva Onjukka, Tine Bjørn Nielsen, Lotte Holm Land, Jörgen Olofsson, Tiziana Rancati, Rebekka Knoph Hagen, Karam Al-Jirf, Christina Ramberg, Anne-Sofie Frøland, Jan Nyman, Mirjana Josipovic, Lone Hoffmann, Kristin Karlsson, André Haraldsson, Azza Khalil
article en

Abstract

Bronchial tumor compression is a strong predictor for grade-5 bleeding, and the most relevant dose parameter appears to be the dose to a small volume of the main and intermediate bronchi.

International Journal of Radiation Oncology*Biology*PhysicsVol. 124(5)
Oslo University Hospital (NO), Karolinska University Hospital (SE), University of Antwerp (BE), University of Southern Denmark (DK), Aarhus University (DK), Sahlgrenska University Hospital (SE), Odense University Hospital (DK), Aarhus University Hospital (DK), Copenhagen University Hospital (DK), Karolinska Institutet (SE), Vejle Sygehus (DK), University Hospital of Umeå (SE), Karlstad Central Hospital (SE), Iridium Kankernetwerk (BE), Skåne University Hospital (SE), Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
Good health and well-being
Openalex Percentile: Top 89%
Lung Cancer Diagnosis and Treatment
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