Circulating Transcriptome Analysis Finds Gene Signatures and Immune Cell Activation and Abundance Predict Response to Immunotherapy in Bladder Cancer

Total RNA sequencing from whole blood provides high-quality data to predict clinical response, survival, and occurrence of irAEs. The use of this type of samples prior to immune checkpoint blockage could improve treatment efficacy and irAEs management.

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Publication Details

Journal
Clinical Cancer Research
Published
2026-01-13
DOI
https://doi.org/10.1158/1078-0432.ccr-25-2306
Primary Topic
Bladder and Urothelial Cancer Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Circulating Transcriptome Analysis Finds Gene Signatures and Immune Cell Activation and Abundance Predict Response to Immunotherapy in Bladder Cancer

Corentin Richard, L. Zitvogel, Éric Tartour, François Ghiringhelli et al.
Clinical Cancer Research
Bladder and Urothelial Cancer Treatments
article

Circulating Transcriptome Analysis Finds Gene Signatures and Immune Cell Activation and Abundance Predict Response to Immunotherapy in Bladder Cancer

Corentin Richard, L. Zitvogel, Éric Tartour, François Ghiringhelli, Romain Boidot, Maha Ayyoub, Sandy Chevrier, Salima Hacein‐Bey‐Abina, Nathalie Chaput, Damotte Diane, Olivier Adotévi, Aurélien Marabelle
article en

Abstract

Total RNA sequencing from whole blood provides high-quality data to predict clinical response, survival, and occurrence of irAEs. The use of this type of samples prior to immune checkpoint blockage could improve treatment efficacy and irAEs management.

Clinical Cancer Research
Centre National de la Recherche Scientifique (FR), Université Toulouse III - Paul Sabatier (FR), Inserm (FR), Université Paris Cité (FR), Université Paris-Saclay (FR), Institut Gustave Roussy (FR), Sorbonne Université (FR), Centre de Recherches en Cancérologie de Toulouse (FR), Centre Hospitalier Universitaire de Besançon (FR), Sorbonne Paris Cité (FR), Centre de Recherche des Cordeliers (FR), Hôpital Cochin (FR), Centre Georges François Leclerc (FR), Methodology and Quality of Life Unit in Oncology (FR), La Ligue Contre le Cancer (FR), Assistance Publique – Hôpitaux de Paris (FR), Centre de recherche en Epidémiologie et Santé des Populations (FR), Hôpital Européen (FR), Université Bourgogne Franche-Comté (FR), Laboratoire d'études sur les monothéismes (FR), Genomic and Immunotherapy Medical Institute (FR), Institut Claudius Regaud (FR), Paris Cardiovascular Research Center (FR), Laboratoire de Recherche Vasculaire Translationnelle (FR), Unité de Technologies Chimiques et Biologiques pour la Santé (FR), Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers (FR), Bicêtre Hospital (FR), Université de Franche-Comté (FR)
Openalex Percentile: Top 88%
Bladder and Urothelial Cancer Treatments
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