Single-cell and immune-context integration identifies basement-membrane/metastasis signatures that sharpen bladder-cancer diagnosis and prognosis
The MBRG-based model effectively predicts BLCA prognosis, integrates mechanisms of basement membrane remodeling, EMT, and immune suppression, and identifies DDR2 and SERPINF1 in CAFs as potential targets for personalized therapy.
Authors
- Wu Long
- Yu Lin (ORCID: https://orcid.org/0000-0003-4633-0745)
- Xiaobing Liu
- Chaoqun Xie
- Xiongfeng Zhang
- Ji Chen
- Rongyin Ren
Institutions
- Loudi Central Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1007/s12672-026-04440-3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00