High-Density Lipoproteins (HDLs) contribute to limiting acute tissue damage: proof of concept in a model of mercury-induced nephrotoxicity

Exogenous HDLs supplementation improves biochemical markers of renal function in vivo and promotes cell survival in vitro in a HgCl<sub>2</sub> toxicity model. These findings reveal a new beneficial property of HDLs, unlike apo B-containing lipoproteins, and underline the importance of such interventions for health support and disease management.

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Publication Details

Journal
Lipids in Health and Disease
Published
2026-01-14
DOI
https://doi.org/10.1186/s12944-025-02857-3
Primary Topic
Mercury impact and mitigation studies
Type
article
Field-Weighted Citation Impact
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article

High-Density Lipoproteins (HDLs) contribute to limiting acute tissue damage: proof of concept in a model of mercury-induced nephrotoxicity

Ian García‐Aguirre, Oscar Oscar Pérez-Méndez, G Richet, Martha G Franco et al.
Lipids in Health and Disease
Mercury impact and mitigation studies
article

High-Density Lipoproteins (HDLs) contribute to limiting acute tissue damage: proof of concept in a model of mercury-induced nephrotoxicity

Ian García‐Aguirre, Oscar Oscar Pérez-Méndez, G Richet, Martha G Franco, Daniel Gómez-Pineda, María Chávez-Canales, Paola Arciga-Portela, Andrea González-Montes-de-Oca, José Manuel Fragoso, Zuriel Osorio-Téllez, Daniel Gómez-Aranguren, María Luna-Luna, Jonathan J. Magaña
article en

Abstract

Exogenous HDLs supplementation improves biochemical markers of renal function in vivo and promotes cell survival in vitro in a HgCl<sub>2</sub> toxicity model. These findings reveal a new beneficial property of HDLs, unlike apo B-containing lipoproteins, and underline the importance of such interventions for health support and disease management.

Lipids in Health and DiseaseVol. 25(1)
Instituto Nacional de Cardiologia (BR), Instituto Nacional de Cardiología (MX), Universidad Nacional Autónoma de México (MX), Tecnológico de Monterrey (MX)
Good health and well-being
Openalex Percentile: Top 89%
Mercury impact and mitigation studies
DOIOpen Access PDFOpenAlex
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