Dysregulation of the microbiota-gut-brain axis induced by chronic pancreatitis mediates anxiety- and depression-like behaviors in mice
CP promotes anxiety- and depression-like behaviors in mice by inducing gut microbiota dysbiosis. This study provides experimental evidence for the use of microbiota-targeted interventions for treating the psychological complications of CP.
Authors
- Chengying Zhu
- Ge Yu (ORCID: https://orcid.org/0000-0002-8300-794X)
- Rong Wan (ORCID: https://orcid.org/0000-0003-1824-7135)
- Leheng Liu (ORCID: https://orcid.org/0000-0002-7046-9205)
- Jingpiao Bao (ORCID: https://orcid.org/0000-0003-1285-142X)
- Kena Zhou (ORCID: https://orcid.org/0000-0002-1681-8830)
- Zhiyuan Cheng
- Han Sun (ORCID: https://orcid.org/0000-0002-7850-9574)
- Chuanyang Wang
- Xi Zhang
- Wenqin Xiao
Institutions
- Shanghai Jiao Tong University (CN)
- Anhui Medical University (CN)
- Shanghai First People's Hospital (CN)
- National Science Centre (PL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1753424
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China