The differential expression profiles of miRNA in serum-derived exosomes and its potential role in age-related hearing loss
Ubiquitination modification, autophagy process, cellular senescence and nervous system regulation may jointly contribute to the core molecular mechanism of ARHL. The hsa-miR-100-5p, hsa-miR-23b-3p, hsa-miR-373-3p, and hsa-miR-27b-3p may preliminarily act as key regulatory factors to participate in the pathophysiological process of ARHL, providing exploratory evidence for their potential application value as molecular markers.
Authors
- J.W. Zhang
- ZhiJi Chen
- Ziyi Tang
- Jing Ke (ORCID: https://orcid.org/0000-0003-4188-7122)
- Shaojing Kuang
- Yang Li (ORCID: https://orcid.org/0000-0003-1590-4718)
- HaiZhu MA
- Guijun Yang
- Wei Yuan
- Kaiye Wang
- Changxiu Peng
- Xiyao Chen
- Xiaoqi Yan
- Jialin Guo
Institutions
- National Medical Products Administration (CN)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fnagi.2025.1694514
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chongqing Municipal Health Commission
- National Natural Science Foundation of China
- Centre Scientifique et Technique du Bâtiment