Ginkgolic acid attenuates echinococcus granulosus infection-induced hepatic fibrosis by inhibiting Smad4 SUMOylation
This study reveals the critical role of SUMOylation modification in CE-associated hepatic fibrosis and elucidates a novel anti-fibrotic mechanism whereby GA targets the SUMOylation-Smad4 axis to regulate the immune microenvironment.
Authors
- Lianghai Wang (ORCID: https://orcid.org/0000-0003-3128-7780)
- Huijiao Jiang
- Xueting Yu
- Xueling Chen
- Jun Hou
- Xinyu Jiang
- Qiuyue Chen
- Xiangwei Wu
- Dan Dong
Institutions
- Shihezi University (CN)
- Xinjiang Production and Construction Corps (CN)
- Shenyang Center for Disease Control and Prevention (CN)
- First Affiliated Hospital of Shihezi University Medical College (CN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1371/journal.pntd.0013497
- Primary Topic
- Parasitic infections in humans and animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00