Clinical characteristics and risk factors of drug-induced hepatotoxicity in cancer patients following repeated chemotherapy cycles

Tumor patients undergoing multiple courses of common chemotherapy drugs exhibit a high incidence of DILI, predominantly moderate in severity. Age ≥60 years, history of alcohol consumption, history of viral hepatitis, underlying liver disease, use of ≥3 chemotherapy drugs, and lack of prophylactic hepatoprotective and cholagogue drugs are independent risk factors for DILI. The first five factors are positively correlated with injury severity, while hepatoprotective and cholagogue drug use is negatively correlated. Clinicians should strengthen monitoring and implement prophylactic interventions for high-risk populations.