Probing intratumoral metabolic compartmentalisation in a patient with fumarate hydratase-deficient renal cancer using clinical hyperpolarised 13C-MRI and mass spectrometry imaging
This study shows the potential of metabolic HP <sup>13</sup>C-MRI to characterise FHd-RCC and how targeting of biopsies to regions of metabolic dysregulation could be used to obtain the tumour samples of greatest clinical significance, which in turn can inform on early and successful response to treatment.
Authors
- Andrew N. Priest (ORCID: https://orcid.org/0000-0002-9771-4290)
- G Hamm
- Tev Aho (ORCID: https://orcid.org/0000-0003-3072-2349)
- Sarah J. Welsh (ORCID: https://orcid.org/0000-0001-5690-2677)
- Heather Hulme (ORCID: https://orcid.org/0000-0002-2987-7397)
- Mary A. McLean (ORCID: https://orcid.org/0000-0002-3752-0179)
- Simon T. Barry (ORCID: https://orcid.org/0000-0002-8511-0588)
- Ruth Therese Casey (ORCID: https://orcid.org/0000-0003-4058-3135)
- Anne Y. Warren (ORCID: https://orcid.org/0000-0002-1170-7867)
- Alixander S. Khan (ORCID: https://orcid.org/0000-0002-9048-9553)
- Joshua Kaggie (ORCID: https://orcid.org/0000-0001-6706-3442)
- Andrew B. Gill (ORCID: https://orcid.org/0000-0002-9287-9563)
- John C. Gallon
- Thomas J. Mitchell (ORCID: https://orcid.org/0000-0003-0761-9503)
- Cara Brodie (ORCID: https://orcid.org/0009-0004-7146-8855)
- Katherine Honan
- James Denholm
- G. C. Stewart (ORCID: https://orcid.org/0000-0001-9097-6573)
- Shubha Anand
- Richard J. A. Goodwin
- Ferdia A. Gallagher
- Marc Dodd
- Cissy Yong
- James Whitworth
- Joao A. G. Duarte
- Ines Horvat-Menih
Institutions
- AstraZeneca (United Kingdom) (GB)
- University of Cambridge (GB)
- Royal Papworth Hospital (GB)
- Cancer Research UK (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Addenbrooke's Hospital (GB)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1038/s43856-025-01371-y
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00