Clinical Characteristics and Spatial Transcriptome Analysis of Non–Small Cell Lung Cancers Exhibiting Early Alectinib Resistance: A Retrospective OLCSG Study
Some ALK-positive lung cancers show early resistance to alectinib. This study found brain metastases and elevated NLR associated with early resistance. Spatial transcriptomics and functional analysis suggested involvement of ANXA1. These results reveal clinical and molecular biomarkers that may guide treatment strategies for early resistance to alectinib.
Authors
- Tadahiro Kuribayashi (ORCID: https://orcid.org/0009-0007-6305-7126)
- Kiichiro Ninomiya (ORCID: https://orcid.org/0000-0002-2134-2865)
- Yuka Kato (ORCID: https://orcid.org/0000-0003-3349-4847)
- Go Makimoto (ORCID: https://orcid.org/0000-0002-0638-8435)
- Kenichiro Kudo
- Naokatsu Horita
- Katsuyuki Hotta (ORCID: https://orcid.org/0000-0002-0112-0843)
- Shoichi Kuyama (ORCID: https://orcid.org/0000-0002-6079-3511)
- Yosuke Togashi
- S. Tomida
- Hiroe Kayatani
- Masaaki Inoue (ORCID: https://orcid.org/0000-0001-6224-9416)
- Yoshinobu Maeda (ORCID: https://orcid.org/0009-0004-0051-0075)
- Hirofumi Inoue (ORCID: https://orcid.org/0009-0001-4413-5746)
- Toshihide Yokoyama
- Keisuke Sugimoto
Institutions
- Okayama University (JP)
- Kurashiki Central Hospital (JP)
- Okayama University Hospital (JP)
- Japanese Red Cross Kobe Hospital (JP)
- Shimonoseki City Hospital (JP)
- Okayama Red Cross General Hospital (JP)
- Kure Kyosai Hospital (JP)
- Iwakuni Medical Center (JP)
- Shikoku Cancer Center (JP)
- Okayama Medical Center (JP)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0545
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ryobi Teien Memory Foundation
- Chugai Pharmaceutical
- Japan Society for the Promotion of Science
- Daiichi Sankyo Europe