The association of risk factors on coronary computed tomography angiography derived atherosclerotic plaque volume - Lessons from the ADVANCE registry
Our data indicate that TPV is significantly higher in participants with CVRF compared to those without. Age demonstrated the strongest association with plaque volume, while the addition of CVRF only modestly increased the AUC. Altogether, age and CVRF were only modestly associated with plaque volume, highlighting the need for further research to fully understand the potential and limitations of plaque imaging assessing the extent and severity of CAD, in patients with and without CVRF.
Authors
- Sarah A. Mullen (ORCID: https://orcid.org/0000-0002-7598-0985)
- Alexander Haenel (ORCID: https://orcid.org/0000-0002-5672-0547)
- B. Nørgaard
- Aaisha Ferkh (ORCID: https://orcid.org/0000-0002-6686-865X)
- B. De Bruyne
- Mark R. Rabbat
- G. Tzimas (ORCID: https://orcid.org/0000-0002-2593-5166)
- Lynne Koweek (ORCID: https://orcid.org/0000-0001-9990-3397)
- P. Douglas
- Whitney Huey (ORCID: https://orcid.org/0009-0000-1976-958X)
- Fionn Coughlan (ORCID: https://orcid.org/0000-0001-5070-5330)
- Philipp Blanke
- Niels PR Sand
- Kavitha Chinnaiyan
- G Pontone
- Timothy Fairbairn
- Jonathon A. Leipsic
- Tomohiro Kawasaki
- John K. Khoo
- Nicholas Ng
- Hironori Kitabata
- Manesh Patel
- Tetsuya Amano
- Ruurt A. Jukema
- Koen Nieman
- Hitoshi Matsuo
- Campbell Rogers
- Jeroen Bax
Institutions
- University of British Columbia Hospital (CA)
- Loyola University Medical Center (US)
- University of British Columbia (CA)
- Aichi Medical University (JP)
- University of Southern Denmark (DK)
- Wakayama Medical University (JP)
- Leiden University Medical Center (NL)
- Liverpool Heart and Chest Hospital NHS Trust (GB)
- Aarhus University Hospital (DK)
- Clinical Research Institute (US)
- Centro Cardiologico Monzino (IT)
- Onze Lieve Vrouwziekenhuis Hospital (BE)
- University Hospital Schleswig-Holstein (DE)
- Region of Southern Denmark (DK)
- Koga Hospital (JP)
- Duke Medical Center (US)
- Beaumont Hospital, Royal Oak (US)
- HeartFlow (United States) (US)
- Stanford Medicine (US)
- St. Paul's Hospital (CA)
- Gifu Heart Center (JP)
- Vrije Universiteit Amsterdam (NL)
- University of Lübeck (DE)
- University of Lausanne (CH)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.120515
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00